The Styrene-Maleic Acid Copolymer: A Versatile Tool in Membrane Research
نویسندگان
چکیده
منابع مشابه
Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates.
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitutio...
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Integral membrane proteins often present daunting challenges for biophysical characterization, a fundamental issue being how to select a surfactant that will optimally preserve the individual structure and functional properties of a given membrane protein. Bacterial reaction centers offer a rare opportunity to compare the properties of an integral membrane protein in different artificial lipid/...
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Modification of Styrene-maleic anhydride copolymer, synthesized in toluene using benzoyl peroxide (BPO) as initiator, through graft copolymerization of hydrophilic monomer, acrylic acid, (AAc), has been carried out in aqueous medium by chemical and gamma radiation methods. Optimum conditions pertaining to maximum percentage of grafting were evaluated as a function of different reaction paramete...
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Challenges in purification and subsequent functionalization of membrane proteins often complicate their biochemical and biophysical characterization. Purification of membrane proteins generally involves replacing the lipids surrounding the protein with detergent molecules, which can affect protein structure and function. Recently, it was shown that styrene-maleic acid copolymers (SMA) can disso...
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Previously, we prepared a pirarubicin (THP)-encapsulated micellar drug using styrene-maleic acid copolymer (SMA) as the drug carrier, in which active THP was non-covalently encapsulated. We have now developed covalently conjugated SMA-THP (SMA-THP conjugate) for further investigation toward clinical development, because covalently linked polymer-drug conjugates are known to be more stable in ci...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.2228